Fox TV said Assange recorded his lines from the UK, where he is fighting extradition to Sweden over alleged sex offences - charges he denies.

The animated comedy is in its 23rd season, making it the longest-running prime-time scripted programme on TV.

The show is contracted to run for another two seasons.

In the 500th episode, entitled At Long Last Leave, the Simpsons are shown sneaking into a secret town hall meeting where they hear they are about to be thrown out of town.

They subsequenty find a welcome in "The Outlands", where Assange is their neighbour.

Previous guest voices on the programme include former Prime Minister Tony Blair, graffiti artist Banksy and novelist Thomas Pynchon.

Once the show's 25th season has been completed, the number of episodes made will stand at 559.

Creator Matt Groening said the writers still had stories to tell, mostly involving "characters we've never dealt with".

"We have a character we call Squeaky-Voiced Teen," he told the Los Angeles Times. "I'd like to know a little bit more about that guy."

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